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Articles by Mark Klinger
HLAResolver: A statistical framework for resolving HLA ambiguity in T-cell response data
Abstract Large-scale models of T-cell recognition require training examples that specify the complete T-cell receptor (TCR)-peptide-human leukocyte antigen (HLA) complex. Multiplexed Identification of T-cell Receptor Antigen Specificity (MIRA) is a high-throughput assay that identifies TCRs associated with responses to specific peptides, but does not determine which HLA presents each peptide.
Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors
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Abstract Background: Memory T cells are records of clonal expansion from prior immune exposures such as infections, vaccines and chronic diseases. Some of the receptors of these expanded T cell clones in a typical immune repertoire are highly public (present in many individuals) because they respond to the same peptide from a prevalent immune exposure, presented by the same Human Leukocyte Antigen (HLA) allele.
By Damon H. May, Steven Woodhouse, Matthew T. Noakes, Kathryn Doroschak, Rebecca Elyanow, Amanda Moore, Tim Hayes, Ruth Taniguchi, Zheng Yang, Rachel Byron, Jamie R Oaks, Haiyin Chen-Harris, Anna Sherwood, Julia Greissl, Bryan Howie, Mark Klinger, Harlan Robins, Edward J. Osborne, Brad Greenfield, John R. Grino
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Frontiers in Immunology
Assessing the convergence of self-report and informant measures for adults with autism spectrum disorder
Introduction Upward of 500,000 children with autism spectrum disorder (ASD) are projected to enter adulthood within the next decade (Autism Speaks, 2013), reflecting the 163% increase in prevalence from 2002 to 2014 (Baio et al., 2018). The lifetime cost of care for an individual with ASD is estimated at upward of $1.4 million and $2.4 million for an individual with ASD and a comorbid intellectual disability.
Understanding Service Usage and Needs for Adults with ASD: The Importance of Living Situation
With the increasing prevalence of adults with autism spectrum disorder (ASD), research examining the service experiences of this population is greatly needed. The current study investigated service use, unmet needs, and obstacles to service access for a large sample of adults with ASD. After accounting for various demographic factors known to impact service usage and needs, living situation was a significant predictor of service use, needs, and obstacles to services.
A scalable multiplex assay enabling assessment of T cell receptor specificity to hundreds of self- and pathogen-derived antigens
Monitoring antigen-specific T cells is critical for the study of immune responses and development of biomarkers and immunotherapeutics. We previously developed and validated a novel multiplex assay (MIRA, or Multiplexed Identification of T cell Receptor Antigen specificity) that combines conventional immune monitoring techniques and TCR repertoire sequencing to assess T cell specificity to large numbers of query antigens.
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