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Articles by Mark Luedde
Indirect mitral annuloplasty in patients with reduced or preserved ejection fraction: A real‐world, single‐centre experience
Introduction Secondary mitral regurgitation (SMR) is a common finding in people with heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction.1 SMR is commonly the expression of either ventricular or atrial remodelling with consequent annular dilatation, papillary muscle displacement and failure of adaptation of otherwise normal mitral leaflets.2 This physiological cascade accelerates HF progression through reduced forward cardiac output, increased left atrial (LA) pressure,...
Overweight, obesity and incident atrial fibrillation: Real‐world evidence from 400 000 patients in Germany
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description dom16637-sup-0001-TableS1.docxWord 2007 document , 14 KB Table S1. Baseline characteristics of the patients with documented BMI values included in versus excluded from the study. REFERENCES 1, , , et al. Impact of obesity on atrial fibrillation pathogenesis and treatment options. J Am Heart Assoc. 2024; 13(1):e032277. doi:10.1161/JAHA.123.032277 2, , , et al.
SGLT2 inhibitors are associated with a reduced incidence of atrial fibrillation in type 2 diabetes mellitus
Corresponding Author Mark Luedde MD Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Campus Giessen, Giessen, Germany Cardiologicum, Bremerhaven, Germany Correspondence Mark Luedde, Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Campus Giessen, Klinikstraße 33, 35392 Giessen, Germany.
The Association between Aortic Valve Stenosis and a Subsequent Diagnosis of Depression in Germany
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Association Between Carpal Tunnel Syndrome and Subsequent Heart Failure Among Adults in Germany
Introduction Carpal tunnel syndrome (CTS), a common nerve compression syndrome, is one of the most common causes of hand surgery.1 Recently, CTS has been associated with to heart failure (HF), mainly through an increased rate of detection of transthyretin (ATTR) cardiac amyloidosis among patients with CTS.2 We investigate the association of CTS with HF among a large collective of outpatients. Methods This retrospective cohort study was based on data from the Disease Analyzer database (IQVIA).
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension To the Editor It is with great pleasure that we read the retrospective study by Doege et al,1 which found a reduced incidence of epilepsy in patients with hypertension receiving angiotensin receptor blockers (ARBs) compared with other antihypertensives. The risk was highest among patients receiving β-blockers and calcium channel blockers (CCBs).
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension-Reply
Association Between Use of Angiotensin Receptor Blockers and Incidence of Epilepsy in Patients With Hypertension—Reply In Reply We are grateful to Ryu and Kuo for their interesting and important comments on our publication, “Association Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy in Patients with Hypertension.1” The authors addressed several points in their letter.
Association Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy
[Skip to Navigation] Figure 1. Flowchart of Study Population ACE indicates angiotensin-converting enzyme; CCBs, calcium channel blocker; ARBs, angiotensin receptor blockers; ICD-10, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10). Figure 2.
Long-term use of proton pump inhibitors (PPIs) is associated with an increased risk of type 2 diabetes
http://orcid.org/0000-0002-2799-2287Sven H Loosen1, Karel Kostev2, Mark Luedde3, Natalia Qvartskhava1, Tom Luedde1, Christoph Roderburg1 1 Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany 2 Epidemiology, IQVIA, Frankfurt, Germany 3 Department of Internal Medicine, Christian Albrechts University of Kiel, Kiel, Germany Correspondence to Dr Sven H Loosen, Clinic for...
Long-term use of proton pump inhibitors (PPIs) is associated with an increased risk of type 2 diabetes
Long-term use of proton pump inhibitors (PPIs) is associated with an increased risk of type 2 diabetes http://orcid.org/0000-0002-2799-2287Sven H Loosen1, Karel Kostev2, Mark Luedde3, Natalia Qvartskhava1, Tom Luedde1, Christoph Roderburg1 1Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany 2Epidemiology, IQVIA, Frankfurt, Germany 3Department of Internal Medicine,...
Serum levels of kisspeptin are elevated in critically ill patients
Kisspeptin serum levels were elevated in the serum of critically ill patients at admission to the ICU, when compared to healthy controls, and remained increased after 72 hours of ICU treatment. Notably, kisspeptin levels were independent of the presence of sepsis and etiology of critical illness. In line, serum concentrations of kisspeptin were not correlated to concentrations of inflammatory cytokines or established sepsis markers.
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