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Mark Sabat

As seen in: Nature, ACS Publications, Cell Press
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Articles by Mark Sabat

Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1

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By Mark Sabat, Daniel Carney, Gloria Hernandez-Torres, Tony Gibson
| dx.doi.org
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Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1

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By Mark Sabat, Daniel Carney, Gloria Hernandez-Torres, Tony Gibson
| ACS Publications
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Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition - Nature Structural & Molecular Biology

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By Zheng Ruan, Emery D. Haley, Ian J. Orozco, Mark Sabat
| Nature Verified
Nature Structural & Molecular Biology (2021)Cite this article Subjects The Original Article was published on 24 June 2021 Correction to: Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-021-00607-4, published online 24 June 2021. In the version of this article initially published, the reference “Liu, D. & Liman, E. R. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc. Natl Acad. Sci. USA (2003)” was omitted.
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Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

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By Zheng Ruan, Emery D. Haley, Ian J. Orozco, Mark Sabat
| Nature Verified
Abstract The Ca2+-activated TRPM5 channel plays essential roles in taste perception and insulin secretion. However, the mechanism by which Ca2+ regulates TRPM5 activity remains elusive. We report cryo-EM structures of the zebrafish TRPM5 in an apo closed state, a Ca2+-bound open state, and an antagonist-bound inhibited state. We define two novel ligand binding sites: a Ca2+ site (CaICD) in the intracellular domain and an antagonist site in the transmembrane domain (TMD).
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