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Markus Bardua on Muck Rack

Markus Bardua

As seen in: European Respiratory Journal
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Articles

Longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum viscoelastic properties, airway infection and inflammation in patients with cystic fibrosis

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By Laura Schaupp, Markus Bardua, Julia Duerr, Stephanie Thee
| European Respiratory Journal Verified
European Respiratory Journal 62: 2202153; DOI: 10.1183/13993003.02153-2022 Abstract Background Recent studies demonstrated that the triple combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI) improves lung function and reduces pulmonary exacerbations in cystic fibrosis (CF) patients with at least one F508del allele.
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Longitudinal Effects of Elexacaftor/Tezacaftor/Ivacaftor on Sputum Viscoelastic Properties, Airway Infection and Inflammation in Patients with Cystic Fibrosis

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By Laura Schaupp, Julia Duerr, Stephanie Thee, Markus Bardua
| European Respiratory Journal Verified
European Respiratory Journal DOI: 10.1183/13993003.02153-2022 Abstract Background Recent studies demonstrated that the triple combination CFTR modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI) improves lung function and reduces pulmonary exacerbations in CF patients with at least one F508del allele. However, effects of ETI on downstream consequences of CFTR dysfunction, i.e. abnormal viscoelastic properties of airway mucus, chronic airway infection and inflammation have not been studied.
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