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Markus G Barbosa on Muck Rack

Markus G Barbosa

As seen in: BioRxiv
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Articles

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism

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By Markus G Barbosa, Andries Heida, Amandine Caillaud, Dyonne Y Vos
| BioRxiv
Abstract Background: Disturbed hepatic cholesterol homeostasis is associated with multiple diseases, including atherosclerotic cardiovascular disease and metabolic dysfunction-associated steatotic liver disease. The endo-lysosomal system is essential for cholesterol uptake and intracellular distribution, yet the mechanisms governing these processes remain incompletely understood.
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The endosomal sorting complex Retromer has a central role in systemic cholesterol homeostasis by controlling endo-lysosomal cholesterol transport in hepatocytes

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By Andries Heida, Markus G Barbosa, W Alfredo Rios-Ocampo, Joel J Tissink
| BioRxiv
Abstract Disturbed cholesterol homeostasis is associated with multiple diseases, such as atherosclerotic cardiovascular disease, lysosomal storage disorders, and neurodegenerative disorders. The endo-lysosomal network plays a central role in the distribution of cholesterol between subcellular membranes, but the processes controlling this transport are still not well-defined.
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