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Articles by Markus Hecker
World’s predominant nitrogen fertilizer induces extreme eutrophication of surface waters in central North America
Abstract Urea, the world’s predominant nitrogen fertilizer, has supported human population growth for the past 60 years, yet its effects on freshwater ecosystems are largely unknown. Here urea additions at ecologically relevant rates tripled summer phytoplankton abundance in replicate agricultural reservoirs with significant responses by most eukaryotic algae, but not cyanobacteria or their toxins.
Developing an Approach for Integrating Chemical Analysis and Transcriptional Changes to Assess Contaminants in Water, Sediment, and Fish
Supporting Information This article includes online-only Supporting Information.
The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion
1 Introduction The aorta is continuously exposed to cyclic deformation due to the pulsatile nature of blood pressure. Central arteries, such as the thoracic ascending and descending aorta, are subjected to high pulsatile stretching and act as cushions for the highly energetic cardiac output.
EcoToxModules: Custom Gene Sets to Organize and Analyze Toxicogenomics Data from Ecological Species
Traditional results from toxicogenomics studies are complex lists of significantly impacted genes or gene sets, which are challenging to synthesize down to actionable results with a clear interpretation.
Toxicity of Aqueous l-Se lenomethionine Exposure to Ear ly Life-Stages of the Fathead Minnow (Pimepha les prome las)
Article First Online: 19 January 2019 Abstract Aqueous exposures to selenomethionine (SeMet), the major form of selenium (Se) in the diet, represent a rapid and simplified method for determining the embryotoxic effects of SeMet. Using fathead minnows (Pimephales promelas) as a model test organism, the objective of this study was to evaluate the effects of waterborne exposure to elevated SeMet on embryos from fertilization to swim-up.
Investigating the Role of Ionoregulatory Processes in the Species- and Life-Stage-Specific Differences in Sensitivity of Rainbow Trout and White Sturgeon to Cadmium
There are huge variations in life-stage- and species-specific sensitivities among the fishes to the exposure with metals; however, the physiological mechanisms underlying these differences are not well understood to date.
A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes
Dioxin-like compounds (DLCs) elicit adverse effects through activation of the aryl hydrocarbon receptor (AHR). Prior investigations demonstrated that sensitivity to activation of AHR1 in an in vitro AHR transactivation assay is predictive of early life stage mortality among birds. The present study investigated the link between sensitivity to activation of AHR1s and AHR2s and early life stage mortality among fishes.
Canada's Paris-pipeline paradox
The Canadian government’s decision to purchase Kinder Morgan’s Trans Mountain pipeline project shortly after ratifying the Paris Agreement on climate change creates an interesting paradox and a national challenge. The environmental implications of pipeline development have already caused British Columbia and Alberta to feud, culminating in an outright trade war between the two provinces. Canadians are clearly divided on energy and climate politics.
Varicose Remodeling of Veins Is Suppressed by 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Inhibitors
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Background Despite the high prevalence of chronic venous insufficiency and varicose veins in the Western world, suitable pharmaceutical therapies for these venous diseases have not been explored to date.
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