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Articles by Markus Möbs
Targetable alterations and personalized treatment in ameloblastoma: results from a prospective observational precision oncology study
Abstract Ameloblastomas are locally aggressive jaw tumors, primarily treated with radical surgery, which often results in significant functional and aesthetic morbidity. Innovative, personalized treatment strategies to reduce patient burden without compromising oncologic control remain lacking. This prospective observational study included comprehensive molecular profiling of 14 patients with ameloblastoma.
Spatial, temporal, and molecular heterogeneity of ADC targets in high-grade serous ovarian carcinoma
Abstract Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for high-grade serous ovarian carcinoma (HGSOC). Patient selection for ADC therapy depends on tumour target expression, making it essential to characterize molecular, spatial, and temporal heterogeneity. We analyzed two HGSOC tissue microarray cohorts: 100 genomically profiled cases (1565 cores) and 64 matched cases with paired adnexal (A), locally advanced (LA), and recurrent (R) samples (2395 cores).
Decoding molecular programs in melanoma brain metastases - Nature Communications
Patient cohorts All procedures performed in this study were in accordance with the ethical standards of the respective institutional research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
CD74 overexpression in cutaneous T-cell lymphoma and its inhibition as a potential therapeutic approach
This paper is only available as a PDF. To read, Please Download here. Cutaneous T-cell lymphomas form a heterogeneous group of non-Hodgkin lymphomas characterized by only poor prognosis in advanced stage. Despite significant progress made in the identification of novel genes and pathways involved in the pathogenesis of cutaneous lymphoma, the therapeutic value of these findings has still to be proven.
Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS
Abstract One of the hallmarks of B lymphoid malignancies is a B cell clone characterized by a unique footprint of clonal immunoglobulin (IG) gene rearrangements that serves as a diagnostic marker for clonality assessment. The EuroClonality/BIOMED-2 assay is currently the gold standard for analyzing IG heavy chain (IGH) and κ light chain (IGK) gene rearrangements of suspected B cell lymphomas.
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