Marlaina R. Stocco on Muck Rack

Marlaina R. Stocco

As seen in: Nature
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Articles

Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments

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By Kevin M. Honeywell, Julian O. Gerson, Murat K. Erdal, Matthew McDonough, Kaylyn K Leung, Nicole Emmons, Jenny Gibson, Wendy Meiring, Joao P. Hespanha, Kevin W. Plaxco, Tod E. Kippin, Marlaina R. Stocco, Kirstin N. Bui
| Nature Verified
Abstract Little is known regarding the extent to which the barriers separating brain subcompartments lead to differential drug transport into these subcompartments and whether such differences impact the behavioral effects of drugs. Against this background, here we have adopted electrochemical aptamer-based (EAB) sensors, a seconds-resolved, in vivo molecular measurement tool, to two tasks.
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