Marlijn Hoeks on Muck Rack

Marlijn Hoeks

As seen in: Color Research & Application, Nature
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Articles

Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

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By Marlijn Hoeks, Tim Bagguley, Argiris Symeonidis, Corine van Marrewijk
| Nature Verified
Introduction Red blood cell transfusions (RBCT) remain the cornerstone of supportive care in lower-risk myelodysplastic syndrome (LRMDS) [1]. Transfusion dependency in LRMDS patients is associated with inferior outcomes, mainly attributed to severe bone marrow failure [2]. However, iron toxicity, due to frequent RBCT or ineffective erythropoiesis, may be an additional negative prognostic factor [3,4,5,6]. Recently, much progress has been made in unraveling the iron metabolism.
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Bone marrow iron score as an indicator for secondary iron overload in acute myeloid leukemia patients

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By Rutger A Middelburg, Dorothea Evers, Marlijn Hoeks, Marian van Kraaij
| Color Research & Application Verified
Secondary iron overload due to red blood cell transfusions (RBCT) is associated with increased morbidity and mortality. However, attention for secondary iron overload and its side effects in patients with hematological malignancies may need improvement. The aim of this study was to determine the number of transfused RBCT needed to reach a maximum bone marrow iron score (BMIS).
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