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Martia Giulia Bigotti on Muck Rack

Martia Giulia Bigotti

Rome
As seen in: BioRxiv
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Articles

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

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By Katja Klein, Esther S. Gan, Maria Anastasina, Martia Giulia Bigotti
| BioRxiv
Abstract The COVID-19 pandemic has shown the need to develop effective therapeutics in preparedness for further epidemics of virus infections that pose a significant threat to human health. As a natural compound antiviral candidate, we focused on α-dystroglycan, a highly glycosylated basement membrane protein that links the extracellular matrix to the intracellular cytoskeleton. Here we show that the N-terminal fragment of α-dystroglycan (α-DGN), as produced in E.
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