Martin Bernhard Dorner on Muck Rack

Martin Bernhard Dorner

As seen in: Nature, Eurosurveillance
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Articles

Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47 - Nature Structural & Molecular Biology

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By Maria Nowakowska, Maren Krüger, Peng Yun Chen, Martin Bernhard Dorner, Andreas Rummel, Miia Lindström
| Nature Verified
Abstract Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene cluster that also encodes four nontoxic proteins (OrfX1, OrfX2, OrfX3 and P47). The orfX gene cluster is also found in the genomes of many non-BoNT-producing bacteria, often alongside genes encoding oral insecticidal toxins. However, the functions of these OrfXs and P47 remain elusive.
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Eurosurveillance | A large travel-associated outbreak of iatrogenic botulism in four European countries following intragastric botulinum neurotoxin injections for weight reduction, Türkiye, February to March 2023

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By Hendrik Wilking, Martin Skiba, Martin Bernhard Dorner, Laura Wilk
| Eurosurveillance
Abstract In March 2023, 34 associated cases of iatrogenic botulism were detected in Germany (30 cases), Switzerland (two cases), Austria (one case), and France (one case). An alert was rapidly disseminated via European Union networks and communication platforms (Food- and Waterborne Diseases and Zoonoses Network, EpiPulse, Early Warning and Response System) and the International Health Regulation mechanism; the outbreak was investigated in a European collaboration.
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