Martin Brandl on Muck Rack

Martin Brandl

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As seen in: European Journal of Pharmaceutical Sciences, Color Research & Application, MDPI, Wochenblatt-Reporter
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Articles

Dissolution-Microdialysis predicts oral bioavailability from phospholipid-based amorphous solid dispersions

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By Martin Brandl Verified
| jpharmsci.org
Keywords In Vitro/In Vivo (IVIVC) Correlation(s) Dissolution Supersaturation Permeability Amorphous Solid Dispersion(s) (ASD) Phospholipid(s) Lipid-based formulation(s) Poorly water-soluble drug(s) Colloid(s) In vitro model(s) Oral absorption Biopharmaceutical characterization Abbreviations ASD (Amorphous solid dispersions) HPL (hydrogenated phospholipid) HPMCAS (hydroxypropylmethylcellulose acetate-succinate) FaSSIF (fasted state simulated intestinal fluid) API (active pharmaceutical...
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Looking behind the Solubilization Curtain: Microdialysis Provides Near-Real-Time Noncolloidal Drug Concentrations during In Vitro Lipolysis

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By Annette Bauer-Brandl, Martin Brandl Verified, Mikkel Højmark Tønning, Felix Paulus
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Due to the increase of poorly water-soluble drugs during the past two decades, (1) candidate-enabling oral formulations have come into focus in oral drug delivery research. One example are lipid-based formulations (LBFs), which are a promising choice for “grease-ball”-like molecules of intermediate to high lipophilicity (logP 4 to 5).
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Untangling “dissolved” drug species from various formulations of a poorly soluble drug: Sampling methods, mechanistic insights, and IVIVC

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By Bayer AG, Martin Brandl Verified
| jpharmsci.org
Keywords Molecular solubility Apparent solubility Supersaturation Microdialysis Biomimetic dissolution Amorphous solid dispersion Poorly soluble drug Non-sink dissolution Drug-rich nanoparticles Enabling formulations Abbreviations API (Active Pharmaceutical Ingredient) ASD (Amorphous Solid Dispersion;BCS, Biopharmaceutics Classification System) DLS (Dynamic light scattering) 3F (FaSSIF/FeSSIF/FaSSGF) FaSSGF (Fasted State Simulated Gastric Fluid) FaSSIF (Fasted State Simulated Intestinal...
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