Martin Dieter Baaske on Muck Rack

Martin Dieter Baaske

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The Smc5/6 complex is a DNA loop-extruding motor - Nature

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By Biswajit Pradhan, Takaharu Kanno, Miki Igarashi, Martin Dieter Baaske, Camilla Björkegren
| Nature Verified
Abstract Structural maintenance of chromosomes (SMC) protein complexes are essential for the spatial organization of chromosomes1. Whereas cohesin and condensin organize chromosomes by extrusion of DNA loops, the molecular functions of the third eukaryotic SMC complex, Smc5/6, remain largely unknown2. Using single-molecule imaging, we show that Smc5/6 forms DNA loops by extrusion.
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