Martin Dunbar
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Full article: Aripiprazole Lauroxil Every 2 Months or Paliperidone Palmitate Monthly for Acute Schizophrenia: A Post Hoc Analysis of PANSS Five-Factor Scores in the ALPINE Trial
Abstract Purpose The randomized, controlled Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness (ALPINE) study (NCT03345979) evaluated the efficacy and safety of aripiprazole lauroxil (AL) administered every-2-months in patients with schizophrenia. Primary results indicating significant improvement in Positive and Negative Syndrome Scale (PANSS) total scores with AL or active control (paliperidone palmitate [PP] monthly) were reported previously.
Aripiprazole lauroxil every 2 months for acute schizophrenia: a post h
Back to Journals » Neuropsychiatric Disease and Treatment » Volume 21 Authors Citrome L , Dunbar M, McGrory JA Received 5 December 2024 Accepted for publication 25 April 2025 Published 14 May 2025 Volume 2025:21 Pages 1047—1055 DOI https://doi.org/10.2147/NDT.S510471 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Taro Kishi Leslie Citrome,1 Martin Dunbar,2 James A McGrory2 1Department of Psychiatry and Behavioral...
Long-Term Safety and Treatment Effect of Olanzapine/Samidorphan
Abstract Objective: Evaluate long-term safety, tolerability, and durability of the effect of olanzapine/samidorphan (OLZ/SAM) for up to 4 years in patients with schizophrenia, schizophreniform disorder, or bipolar I disorder (BD-I). Methods: This phase 3, multicenter, open-label, long-term extension (conducted June 2017–September 2023) assessed OLZ/SAM in patients completing the ENLIGHTEN clinical program. Patients received ≥2–4 years of additional treatment.
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