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Highlights • The BAF complex consists of three modules arranged in a C shape around the nucleosome • Endogenous-specific densities map to the ARID1A and SMARCC C termini, SS18, and BCL7A • SMARCA4 SnAc/post-SnAc and SMARCB1 CTD regions bilaterally engage NCP acidic patch sites • Disease mutations cluster at key structural interfaces, attenuating remodeling activity Summary Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling complexes that regulate genomic architecture.
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