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Martin Gustavsson

As seen in: Nature, PLOS Biology, BioRxiv, eLife
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Articles

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor - Nature

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By Qiuyan Chen, Christopher Schafer, Somnath Mukherjee, Kai Wang, Martin Gustavsson, James Fuller, Genki Terashi, Daisuke Kihara, Anthony A. Kossiakoff, Tracy M. Handel, Thomas D. Lamme
| Nature Verified
Abstract Unique phosphorylation ‘barcodes’ installed in different regions of an active seven-transmembrane receptor by different G-protein-coupled receptor (GPCR) kinases (GRKs) have been proposed to promote distinct cellular outcomes1, but it is unclear whether or how arrestins differentially engage these barcodes.
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Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

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By Christopher Schafer, Martin Gustavsson, Tracy M. Handel, David Millar
| eLife
eLife Assessment This manuscript describes the characterization of the conformational dynamics of two chemokine receptors at the single-molecule level using FRET. The authors make a convincing case for attributing the distinct interaction and pharmacology of the two receptors to differences in their conformational energy landscape. These important findings will be of interest to scientists working on activation mechanisms of GPCRs and signal transduction.
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Modeling and analysis of the rapid aerobic metabolism of Geobacillus sp. LC300

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By Martin Gustavsson, Verena Sievers
| avhandlingar.se
Nyckelord: Geobacillus sp. LC300; thermophile; respiration; genome-scale modeling; quantitative physiology; optimal growth; chemostat; enzyme-constrained modeling; proteomics; Geobacillus sp. LC300; termofil; respiration; genomskalemodellering; kvantitativ fysiologi; optimal tillväxt; kemostat; enzymbegränsad modellering; proteomik; Biotechnology; Bioteknologi; Sammanfattning: To mitigate climate change, global greenhouse gas emissions must be halved before 2030.
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