Martina Bruna Violatto

Abstract Despite their anti-inflammatory activity, corticosteroids are limited in clinic due to poor selectivity and their side effects. The ability to cross biological barriers makes them powerful yet unspecific, leading to toxicity and a low therapeutic index that limits their chronic use in autoimmune, inflammatory, and infectious diseases. It is needed another approachfor innovative targeted delivery strategies.

3.2. In Vivo Studies The experimental design developed for this study is reported in Figure 2. To understand the impact of NP functionalization, a biodistribution study was performed in WT and SOD1G93A mice, which were treated with ANANAS, ANANAS-ApoE or the vehicle and then sacrificed 30′, 4 h, and 24 h after administration (Figure 2A).