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Keywords polygenic risk score family history coronary heart disease risk prediction risk reclassification prevention coronary artery disease risk assessment Get full text access Log in, subscribe or purchase for full access. References 1. GBD 2021 Forecasting Collaborators Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021 Lancet. 2024; 403:2204-2256 2.
The authors have declared no competing interest. The MIGENES clinical trial was conducted as a genomic medicine implementation study during phase II of the eMERGE Network and was supported by grant U01HG006379 from the National Human Genome Research Institute (NHGRI) and by the Mayo Center for Individualized Medicine. Follow-up was enabled by funding for phase IV of the eMERGE Network.
Abstract Severe hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether implementing clinical decision support (CDS) was associated with lower low-density lipoprotein cholesterol (LDL-C) in patients with severe hypercholesterolemia/possible FH (LDL-C ≥ 190 mg/dL).
The Brussels attacks are the latest in a string of terrorist onslaughts that have left our hearts heavier. The attacks are becoming more sophisticated, more lethal, and more adept at maiming and ending lives. We think we are wholeheartedly invested in the war against terror, yet the attacks only rise in atrocity. Today no one is immune. There is no safe haven. And a phenomenon that has once been the reserve of the Middle East is now a global nightmare.
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