Marziogiuseppe Gentile on Muck Rack

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Articles

The predominant binding mode of Palmatine to DNA

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By Francesco Talotta, Jean Tremblay, Leticia González, Marziogiuseppe Gentile
| biorxiv.org
Abstract Palmatine is a protoberberine alkaloid, which may produce singlet oxygen under visible light irradiation and binds to DNA. The fact that singlet oxygen activation in palmatine may be triggered by environmental conditions, and in particular its interaction with nucleic acids, makes it a most suitable candidate for photodynamic therapy and DNA-targeted non-invasive anticancer strategies.
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