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Masuharu Hirano on Muck Rack

Masuharu Hirano

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Oral administration of a xanthine oxidoreductase inhibitor suppresses retinal degeneration and preserves ocular ATP levels

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By Dedy Ariwansa, Yoshihiro Abiko, Durga Paudel, Shiho Yoshida, Ken Okamoto, Nana Sato, Koji Nagata, Miki Hiraoka, Masuharu Hirano
| Nature Verified
Abstract Retinal degeneration results in irreversible visual impairment. In a neurodegenerative animal model, xanthine oxidoreductase inhibitor application reduced disease severity. The present study examined the effect of a novel xanthine oxidoreductase (XOR) inhibitor, NC-2500, on a spontaneous retinal degeneration rat model via oral administration. Three-and-a half-week-old RCS (-/-) rats received formulated NC-2500 orally daily for 19 days, and 2-week-old RCS (+/+) rats received it for 21 days.
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