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Matanel Yheskel on Muck Rack

Matanel Yheskel

As seen in: BioRxiv
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Articles

The histone demethylase KDM5 has insulator activity in the brain

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By Richard Kelly, Simone Sidoli, Matanel Yheskel, Melissa A Castiglione
| BioRxiv
Abstract KDM5 family proteins are best known for their demethylation of the promoter proximal chromatin mark H3K4me3. KDM5-regulated transcription is critical in the brain, with variants in the X-linked paralog KDM5C causing the intellectual disability (ID) disorder Claes-Jensen syndrome. Although the demethylase activity of KDM5C is known to be important for neuronal function, the contribution of non-enzymatic activities remain less characterized.
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