Matea Kevo Jurić

Abstract Tetrahydroisoquinoline (THIQ) oximes have been investigated as antidotes for poisoning by toxic organophosphorus compounds. Recent studies have shown that some THIQ oximes induce cytotoxic effects and trigger apoptosis in various cell types. Since this pathway activation is desirable for anticancer drugs, we further explored the effects of three selected THIQ oximes on well-known cancer cell models: breast (MDA-MB-231 and MCF-7), prostate (PC-3) cancer and malignant glioblastoma (U251).

1. Introduction The production of cellular oxidizing, nitrating, and halogenating species, involving the superoxide radical anion (O2•−), hydrogen peroxide (H2O2), hypochlorous acid (HOCl), peroxynitrite (ONOO−), and the hydroxyl radical (•OH), collectively termed reactive oxygen species (ROS), is a common feature of pathological states involving an inflammatory component () [1,2].

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