Mathew Ebin Sovichan on Muck Rack

Mathew Ebin Sovichan

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Articles

Production and characterization of gigastasin, a leech-derived inhibitor of complement and coagulation pathways

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By Aleksandra Blagojevic, Peter Rüthemann, Marco Mannes, Markus S Huber-Lang, Daniel Ricklin, Kevin Widmer, Dilara Caglar, Mateja Tiric, Mathew Ebin Sovichan
| Nature Verified
Abstract The complement and coagulation systems protect against injury and infection, but ill-controlled activation may cause clinical complications. Despite their efficacy in defined indications, approved complement and coagulation inhibitors remain poorly effective in complex thromboinflammatory disorders. Given their ability to broadly impair host defense, parasitic inhibitors provide a promising therapeutic avenue.
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