Mathison JC on Muck Rack

Mathison JC

As seen in: Color Research & Application
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Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

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By Wright SD, Mathison JC, Tobias PS
| Color Research & Application
Summary An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4 (TLR4) – but also in a better appreciation of the complexity of the signalling pathways activated by LPS.
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