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Matia Bernardi on Muck Rack

Matia Bernardi

As seen in: Nature
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Articles

PYGO2 is overexpressed in multiple myeloma patients with 1q21 amplification, driving plasma cell proliferation and cell cycle progression

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By Nicolas Thomas Iannozzi, Paola Storti, Rosanna Vescovini, Andrea Poletti, Valentina Franceschi, Denise Toscani, Mattia Dessena, Oxana Lungu, Bruno Lorusso, Federico Quaini, Luca Agnelli, Gaetano Donofrio, Nicola Giuliani, Camilla Sitzia, Giannalisa Todaro, Gabriella Sammarelli, Vincenzo Raimondi, Fazel Mohammadi, Matteo Scita, Matia Bernardi, Stefania Ricci
| Nature Verified
Abstract Chromosome 1q21 copy number alterations (1q21+) are among the most frequent secondary events in multiple myeloma (MM), correlating with poor prognosis and therapy resistance. However, the molecular drivers of this lesion remain poorly defined. Here, we identify PYGO2, a Wnt/β-catenin co-activator located on 1q21, as a critical effector of MM progression.
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