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Matías Bertone Arolfo on Muck Rack

Matías Bertone Arolfo

As seen in: BioRxiv
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Articles

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components

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By Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi
| BioRxiv
Abstract Extracellular vesicles (EVs) play a critical role in the development of neural cells in the central nervous system (CNS). Human neural rosettes (hNRs) are radial cell structures that assemble from induced pluripotent stem cells (hiPSCs) and recapitulate some stages of neural tube morphogenesis. Here we show that hiPSCs and hNRs secrete EVs (hiPSC-EVs and hNR-EVs) with distinct protein cargoes. Remarkably, hNR-EVs carry neuronal and glial cellular components involved in CNS development.
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