Matias Knuuttila on Muck Rack

Matias Knuuttila

As seen in: Nature, MDPI
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Articles

Cancers | Free Full-Text | Zoledronic Acid Prevents Bone Resorption Caused by the Combination of Radium-223, Abiraterone Acetate, and Prednisone in an Intratibial Prostate Cancer Mouse Model

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By Mari I. Suominen, Matias Knuuttila, Timothy Wilson, Birgitta Sjöholm
| MDPI
1. Introduction Radium-223 dichloride (radium-223, Xofigo®) is a targeted alpha therapy that homes to areas of increased bone turnover, such as bone metastases, and induces DNA double-strand breaks in cancer cells, osteoblasts, and osteoclasts [1,2]. Radium-223 is actively incorporated into bone by osteoblasts, but passive incorporation into bone mineral hydroxyapatite is also observed.
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Enhanced Antitumor Efficacy of Radium-223 and Enzalutamide in the Intratibial LNCaP Prostate Cancer Model

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By Andreas Schlicker, Mari I. Suominen, Matias Knuuttila, Christoph A. Schatz
| MDPI
Altmetric share Share announcement Help format_quote Cite thumb_up ... Endorse textsms ... Comment Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI. Get Information clear Font Type: Arial Georgia Verdana Line Spacing:    Column Width:    Open AccessArticle by Mari I.
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