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Matias M. Falco on Muck Rack

Matias M. Falco

As seen in: Nature, Infobae, Cell Reports Medicine
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Articles

Multi-omics analysis reveals the attenuation of the interferon pathway as a driver of chemo-refractory ovarian cancer

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By Daria Afenteva, Rong Yu, Anna Rajavuori, Marina Salvadores, Inga-Maria Launonen, Kari Lavikka, Kaiyang Zhang, Giovanni Marchi, Sanaz Jamalzadeh, Veli-Matti Isoviita, Yilin Li, Erdogan Pekcan Erkan, Matias M. Falco, Matías Falco, Alexandra Lahtinen, Jaana Oikkonen, Sakari Hietanen, Anna Vähärautio, Anni Virtanen, Anniina Färkkilä, Johanna Hynninen, Taru A. Muranen, Jussi Taipale, Sampsa Hautaniemi, Anna Pirttikoski, Giulia Micoli, Daniela Ungureanu, Inderpreet Sur
| Cell Reports Medicine Verified
Introduction Chemotherapy resistance is the leading cause of cancer-related deaths, representing the most critical unresolved challenge in oncology. The issue of chemotherapy resistance is particularly acute in ovarian high-grade serous carcinoma (HGSC), which is one of the deadliest gynecological malignancies.
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Tracing back primed resistance in cancer via sister cells - Nature Communications

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By Jun Dai, Shuyu Zheng, Matias M. Falco, Matías Falco, Johanna Eriksson, Fernando Pérez-Villatoro, Olli Dufva, Ali Amiryousefi, Anniina Färkkilä, Satu Mustjoki, Liisa Kauppi, Jing Tang, Sanna Pikkusaari
| Nature Verified
Abstract Exploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating high resolution analysis. Here, we present ReSisTrace that uses shared transcriptomic features of sister cells to predict the states priming treatment resistance.
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miQC: An adaptive probabilistic framework for quality control of single-cell RNA-sequencing data

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By Ariel A. Hippen, Matias M. Falco, Matías Falco, Lukas Weber, Erdogan Pekcan Erkan
| BioRxiv
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