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Articles

Efficient complement-mediated clearance of immunosuppressed T cells by macrophages

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By Matlung HL, Van Bruggen R, Gankema AAF, Fernández-Hermira S
| ncbi.nlm.nih.gov
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
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The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.

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By Matlung HL
| ncbi.nlm.nih.gov
Immune checkpoint inhibitors, including those targeting CTLA-4/B7 and the PD-1/PD-L1 inhibitory pathways, are now available for clinical use in cancer patients, with other interesting checkpoint inhibitors being currently in development. Most of these have the purpose to promote adaptive T cell-mediated immunity against cancer. Here, we review another checkpoint acting to potentiate the activity of innate immune cells towards cancer.
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