Matsuyama City

Von Ralph Dane M. Herbuela1 Tomonori Karita1* Akihiro Toya2 Yoshiya Furukawa3 Shuichiro Senba4 Eiko Onishi4 Tatsuo Saeki4 1Center for Inclusive Education, Faculty of Education, Ehime University, Japan 2Graduate School of Humanities and Social Sciences, Hiroshima University, Japan 3Graduate School of Humanities, Fukuoka University, Japan 4DigitalPia Co., Ltd., Japan The final, formatted version of the article will be published soon.

Dear editor We read with great interest, the article by Yumeng Gao et al, who reported that that SARS-CoV-2 was contagious during the incubation period, with a median incubation period of 10 days. However, no studies have so far reported the incubation period of the B.1.1.7 variant that was reported to have a substantial transmission advantage over other lineages.

Keywords allergy testing anaphylaxis anaesthesia MRGPRX2 neuromuscular blocking agent non-IgE-mediated allergic reaction rocuronium The perioperative drugs most likely to cause anaphylaxis are antibiotics, neuromuscular blocking agents (NMBAs) and opioids. Recent studies have shown that NMBAs and opioids directly stimulate the Mas-related G protein-coupled receptor b2 (Mrgprb2), which is specifically expressed by mouse mast cells and which induces mast cell histamine release.