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Articles by Matthew Meyer
Plasma eMTBR-tau243 and p-tau205 as T2 biomarkers for biological staging and prognosis in Alzheimer’s disease
Abstract Plasma biomarkers that reflect distinct stages of Alzheimer’s disease (AD) could enable scalable biological staging. We evaluated phosphorylated tau (p-tau) species across multiple analytical platforms and the endogenously cleaved microtubule-binding region containing residue 243 (eMTBR-tau243) using a dedicated LC-MS/MS platform in a well-characterized cohort with amyloid PET and a subset with tau PET.
Artificial intelligence-enabled analysis of electron micrographs to assess mitochondrial morphology in triple-negative breast cancer
Abstract Advancements in transmission electron microscopy (TEM) have enabled in-depth studies of biological specimens, offering new avenues to large-scale imaging experiments with subcellular resolution. Mitochondrial morphology is of growing interest in cancer biology due to its crucial role in regulating the multi-faceted functions of mitochondria.
NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Age-related decline in oocyte quality increases the risk of infertility, miscarriage, and birth defects. Mitochondrial dysfunction is a key contributor to this decline.
By Kateryna Murlanova, xinfeng Zhang, Dmitri A. Kalashnikov, Avery A Ahmed, Tessa E. Steenwinkel, Bethany K Patton, Peixin Jiang, Matthew Meyer, Mei Leng, Alexander B. Saltzman, Elizabeth S. Anaya, Momal Sharif, Laurie J McKenzie, Laura Detti, Anna Malovannaya, Sean M. Hartig, Stephanie A. Pangas, Jaspreet K. Rishi
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Science Magazine
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A rationally designed scalable thin film nanocomposite cation exchange membrane for precise lithium extraction - Nature Communications
Abstract Precise separation of ions of the same polarity and similar valence and size remains a critical need in resource recovery from waste streams. Here, we report the rational design and scalable fabrication of a thin film nanocomposite (TFN) cation exchange membrane to achieve precise selectivity for lithium over competing cations.
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis - Nature Communications
Abstract MicroRNA-mediated post-transcriptional regulation of lung alveolar type 2 (AT2) and AT1 cell differentiation remains understudied. Here, we demonstrate that the let-7 miRNA family plays a homeostatic role in AT2 quiescence by preventing the uncontrolled accumulation of AT2 transitional cells and promoting AT1 differentiation.
FDA’s LDT Final Rule Rejected by Federal District Court in Texas | JD Supra
As Wilson Sonsini previously reported,1the U.S. Food and Drug Administration (FDA) had been preparing the industry to comply with the 2024 LDT Final Rule, which phases out the FDA’s enforcement discretion policy for laboratory developed tests (LDTs) and phases in device requirements starting in May 2025. But legal challenges against the LDT Final Rule have prevailed.
Diagnostics | Free Full-Text | PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations That Are Used with Plasma Amyloid-β42/40 in a Multianalyte A
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
"The Tardigrade Damage Suppressor Protein Dsup Promotes DNA Damage in N" by Rocio Diaz Escarcega, Abhijeet A Patil et al.
Abstract Tardigrades are microscopic invertebrates, which are capable of withstanding extreme environmental conditions, including high levels of radiation. A Tardigrade protein, Dsup (Damage Suppressor), protects the Tardigrade's DNA during harsh environmental stress and X-rays. When expressed in cancer cells, Dsup protects DNA from single- and double-strand breaks (DSBs) induced by radiation, increases survival of irradiated cells, and protects DNA from reactive oxygen species.
PrecivityAD2™ Blood Test: Analytical Validation of an LC-MS/MS Assay for Quantifying Plasma Phospho-tau217 and Non-Phospho-tau217 Peptide Concentrations that are Used with Plasma Amyloid-β42/40 in a Multiple Analyte Assay with Algorithm for Detecting Brai
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 19 June 2024 / Approved: 19 June 2024 / Online: 20 June 2024 (04:41:52 CEST) Eastwood, S. M.; Meyer, M. R.; Kirmess, K. M.; Wente-Roth, T. L.; Irvin, F.; Holubasch, M. S.; Verghese, P. B.; West, T.; Braunstein, J. B.; Yarasheski, K. E.; Contois, J. H.
Phase transition of GvpU regulates gas vesicle clustering in bacteria - Nature Microbiology
Abstract Gas vesicles (GVs) are microbial protein organelles that support cellular buoyancy. GV engineering has multiple applications, including reporter gene imaging, acoustic control and payload delivery. GVs often cluster into a honeycomb pattern to minimize occupancy of the cytosol. The underlying molecular mechanism and the influence on cellular physiology remain unknown.
50‐nm Gas‐filled Protein Nanostructures to Enable the Access of Lymphatic Cells by Ultrasound Technologies
Ultrasound imaging and ultrasound-mediated gene and drug delivery are rapidly advancing diagnostic and therapeutic methods; however, their use is often limited by the need of microbubbles, which cannot transverse many biological barriers due to their large size.
SWAN, Water Princess
Campaign Rewards FAQ Community Welcome to "SWAN, Water Princess" Kickstarter campaign. Thank you for joining me on this journey. I'm Kayden Phoenix the Writer/Creator of Swan, Water Princess graphic novel. I'm a third generation Chicana from East Los Angeles. I come from an entertainment industry background and when I was thinking about what I wanted to see on the big screen, I noticed the industry dominated standard- complete with character generalizations.
FatCat - Clothing Re-Imagined
Campaign Rewards FAQ 3 Community Welcome to the future of fashion – welcome to FatCat, where innovation meets versatility in the world of clothing. We've embarked on a mission to redefine how you experience comfort and style, creating garments that effortlessly adapt to any situation life throws your way. The Challenge: Crafting clothes that cater to every scenario, from your daily hustle to unexpected adventures, isn't a walk in the park.
Kitty Winterland Enamel Pins and Stickers
Campaign Rewards FAQ Community Hello! I am Dinojar, I am back with more cute series of enamel pins and stickers! ♡ This campaign is my 22ndKickstarter Campaign! You can check out my previous Kickstarter campaign with a total of more than thousands pledges! Welcome to "Kitty Winterland" – a whimsical world of holiday enchantment in the form of adorable cat enamel pins.! 🎉 Each design captures the joy of the season, creating a mini winter wonderland wherever you go.
Filamentous virus-like particles are present in coral dinoflagellates across genera and ocean basins - The ISME Journal
Abstract Filamentous viruses are hypothesized to play a role in stony coral tissue loss disease (SCTLD) through infection of the endosymbiotic dinoflagellates (Family Symbiodiniaceae) of corals. To evaluate this hypothesis, it is critical to understand the global distribution of filamentous virus infections across the genetic diversity of Symbiodiniaceae hosts.
Florida Appellate Court Provides Further Guidance Regarding New Summary Judgment Rule | JD Supra
In a recent opinion, Florida’s First District Court of Appeal provided further guidance regarding the changes to Florida’s summary judgment rule. See Whitlow v. Tallahassee Memorial Healthcare, Inc., --- So. 3d ---, Case No. 1D21-3413 (Fla. 1st DCA Aug. 16, 2023). The Whitlow opinion provides a thoughtful and scholarly discussion regarding the importance of jury trials, the purpose of summary judgment proceedings, and the practical impacts of the new summary judgment rule.
Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state - British Journal of Cancer
Abstract Background Cisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired resistance. We hypothesised that tumours acquire CDDP resistance through an enhanced reductive state dependent on metabolic rewiring.
Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment - Oncogene
Abstract Neoadjuvant chemotherapy (NACT) used for triple negative breast cancer (TNBC) eradicates tumors in ~45% of patients. Unfortunately, TNBC patients with substantial residual cancer burden have poor metastasis free and overall survival rates. We previously demonstrated mitochondrial oxidative phosphorylation (OXPHOS) was elevated and was a unique therapeutic dependency of residual TNBC cells surviving NACT.
Clinical implications of preoperative echocardiographic findings on cardiovascular outcomes following vascular surgery: An observational trial
PLOS ONE, Jan 2023 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0280531&type=printable Matthew J. Meyer, Slater A. Jameson, Edward J. Gillig, Ankur Aggarwal, Sarah J. Ratcliffe, Mary Baldwin, Karen E. Singh, W. Darrin Clouse, Randal S. Blank. , PLOS ONE, 2023, Volume 18, Issue 1, DOI: 10.1371/journal.pone.0280531
Clinical implications of preoperative echocardiographic findings on cardiovascular outcomes following vascular surgery: An observational trial
Loading metrics Open Access Peer-reviewed Research Article Abstract Introduction Peripheral artery disease and cardiac disease are often comorbid conditions. Echocardiography is a diagnostic tool that can be performed preoperatively to risk stratify patients by a functional cardiac test. We hypothesized that ventricular dysfunction and valvular lesions were associated with an increased incidence of expanded major adverse cardiac events (Expanded MACE).
Florida Preliminary Injunctions Must Merely Preserve the Status Quo | JD Supra
In a recent case, Florida’s Second District Court of Appeal offered a reminder that the fundamental—and limited—purpose of a preliminary injunction is to maintain the status quo.
You Can’t Run From That Arbitration Covenant Running With The Land | JD Supra
In a recent case, the Florida Supreme Court held that an arbitration covenant contained in a developer’s original deed also bound the second owner. The case serves as a good reminder that, although a subsequent owner of residential property might not think to even review the original deed, such a review is necessary because that original deed may contain provisions that bind subsequent owners. See Hayslip v. U.S. Home Corporation, --- So. 3d ---, Case No. SC19-1371 (Fla. Jan. 22, 2022).
The Courts Really Will Enforce That Operating Agreement As Written | JD Supra
More than one business owner this week has wondered aloud: “Why is my lawyer spending so much time (and, therefore, money) on the minutiae of the Operating Agreement? Does any of that matter, anyway?” In response to that question, Florida’s Third District Court of Appeal (Third DCA) reminds us that the rights granted by an Operating Agreement will be enforced as they are written. GG Investment Realty, Inc. v.
No, A Perpetually-Unfair Commission-Splitting Agreement Is Not A Restraint Of Trade | JD Supra
In a recent case that is interesting reading for both antitrust lawyers and insurance agents, which probably does not happen often, Florida’s Second District Court of Appeal (“Second DCA”) held that a commission-splitting agreement—even a very lopsided one—should not be analyzed under Florida’s restrictive covenant statute (Fla. Stat. § 542.335) because such an agreement is not a “restraint of trade” under Florida law. Capital Wealth Advisors, LLC v.
Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment
Key Points Question Is an amyloid probability score based on a mass spectrometry–based blood test measuring plasma amyloid β 42:40 ratio and apoE proteotype plus age, associated with identifying brain amyloidosis among patients with cognitive impairment? Findings In this cohort study of 686 participants from 2 separate studies, the developed Amyloid Probability Score showed high concordance with amyloid PET status, with an area under the curve of 0.88 and overall accuracy of 81%.
Update 23: Otonjoro · The Fox's Wedding: a Compendium of Japanese Folklore
All or nothing. This project will only be funded if it reaches its goal by Sun, January 3 2021 2:59 PM UTC +00:00.
The Prevalence of Abnormal Spinopelvic Relationships in Patients Presenting for Primary Total Hip Arthroplasty
Abstract Background The prevalence of an abnormal spinopelvic relationship in patients presenting for primary total hip arthroplasty (THA) is not well known. The purpose of this study was to identify the prevalence of abnormal spinopelvic relationships in patients presenting for primary THA. Methods A retrospective chart review of 338 consecutive, nonselected patients undergoing primary THA from the practice of 2 fellowship-trained adult reconstruction surgeons was performed (J.E.O. and T.S.B.).
New Hepatitis C Diagnoses in Ontario, Canada are associated with the Local Prescription Patterns of a Controlled Release Opioid
ORIGINAL PAPER Matthew Meyer London Health Sciences Centre, London, Ontario, Canada Department of Epidemiology and Biostatistics, Western University, London, Ontario Ivey International Centre for Health Innovation, Ivey Business School, Western University, London, Ontario Search for more papers by this author Lise Bondy Corresponding Author E-mail address: lise.bondy@sjhc.london.on.ca https://orcid.org/0000-0003-1692-7217 Division of Infectious Diseases, Western University, London, Ontario...
Want to Avoid Paying Rule 41(d) Costs? Then Re-File in State Instead of Federal Court | Lexology
We have all seen this before: a plaintiff decides to dismiss and then re-file. But wait, you say, there’s a downside to doing that, which is subjecting the plaintiff to costs pursuant to Federal Rule of Civil Procedure 41(d). That’s generally true, but according to the Eleventh Circuit, it’s not true if the plaintiff re-files in state court. See Sargeant v. Hall, Case No. 18-15205 (11th Cir. March 2, 2020).
No Discovery Allowed Of Special Litigation Committee Regarding Its Evaluation Of Proposed Derivative Claims | Lexology
Disputes between owners of closely-held businesses usually include allegations that one of the owners caused financial harm to the business. For example: allegations of self-dealing or stealing corporate opportunities. These types of claims oftentimes belong to the business entity, rather than to the individual owners of the business, which means that an aggrieved business owner cannot bring a claim directly.
Trump should spend $5 billion on the opioid epidemic, not the border wall | Opinion
The President is holding the federal government hostage for a $5 billion wall he claims will make us safer. He continues to push his false narrative that the southern border represents “a crisis of the heart and a crisis of the soul.” Meanwhile many local leaders across this country, Republicans and Democrats, are forced to confront a real crisis, one that grows more deadly and urgent every day.
‘Shame on you’: Furious Florida shooting survivors lead call against lawmakers
FORT LAUDERDALE, Fla. — In an emotional rally in Fort Lauderdale today, politicians and Marjory Stoneman Douglas students called for a ban on weapons like the one used to kill 17 people at the Florida high school. Speakers urged voters to kick out lawmakers who oppose the move or who take money from the National Rifle Association. In a fiery speech, senior Emma Gonzalez demanded national lawmakers do something to prevent mass school shootings.
How a rare heart surgery helped make music for the NFL - Philly
The Eagles have endured plenty of medical setbacks during this unlikely football season, but those are nothing compared with the ordeal of a Levittown man who provided the soundtrack for some key gridiron moments. Six years ago, Justin Vigile and his mother were making plans for his funeral. Those discussions turned out to be extremely premature, as Vigile, now 28, underwent a rare heart surgery at the Mayo Clinic — turning him from bedridden invalid back into a promising heavy-metal musician.
What if IPRs are Found Unconstitutional in Oil States?
On November 27, the Supreme Court will hear arguments in Oil States Energy Services, LLC v. Greene’s Energy Group, LLC. The issue is: Whether inter partes review, an adversarial process used by the Patent and Trademark Office (PTO) to analyze the validity of existing patents, violates the Constitution by extinguishing private property rights through a non-Article III forum without a jury.
Late September Surge at the ITC: Ten New Section 337 Complaints In Two Weeks
Your first step to building a free, personalized, morning email brief covering pertinent authors and topics on JD Supra: Already signed up? Log in here By using the service, you signify your acceptance of JD Supra provides users with access to its legal industry publishing services (the "Service") through its website (the "Website") as well as through other sources.
Kickstarter >> The Book of the Hakutaku: a Bestiary of Japanese Monsters by Matthew Meyer
The Book of the Hakutaku is an illustrated bestiary of yokai—the spirits, monsters, and ghosts from traditional Japanese folklore. It is the third volume of my yokai encyclopedia. It has over 100 yokai, each one translated from Japanese folklore and illustrated by me.My first and second volumes, The Night Parade of One Hundred Demons and The Hour of Meeting Evil Spirits, were both funded on Kickstarter.
Erik Johansson. One of the best photographers/surrealist photo-manipulators I've seen.
Explore Paths, Roads, and more!Explore related topicsErik Johansson. One of the best photographers/surrealist photo-manipulators I've seen.See MoreThe Flying Tortoise: Swedish Photographer Erik Johansson Does Weird And Surreal Things With Photographs...See MoreDes montages surréalistes et impressionants d'Erik Johanssontéléchargement (6)See MoreAnyone know the name of the artist? Know I have seen it (in a behind the scenes look at the ship photo), but can't remember.
Assholes: A Theory of Donald Trump
Almost everyone now knows that Donald Trump is an asshole. Much to his credit, Aaron James pointed this out in Assholes: A Theory (Anchor Books 2012) well before Trump took center stage in American politics. In his new book, James sets out to develop this idea in greater detail. According to the back cover, the book does not ask whether Trump is an asshole. This much is assumed. Instead, it raises the further question: What sort of asshole is Trump?
Assholes: A Theory of Donald Trump
Almost everyone now knows that Donald Trump is an asshole. Much to his credit, Aaron James pointed this out in Assholes: A Theory (Anchor Books 2012) well before Trump took center stage in American politics. In his new book, James sets out to develop this idea in greater detail. According to the back cover, the book does not ask whether Trump is an asshole. This much is assumed. Instead, it raises the further question: What sort of asshole is Trump?
Determining the Need for In-Patient Rehabilitation Services Post-Stroke: Results from Eight Ontario Hospitals
Determining the Need for In-Patient Rehabilitation Services Post-Stroke: Results from Eight Ontario Hospitals Background: The number of patients requiring in-patient rehabilitation services following acute stroke is unknown. Methods: All consecutive patients admitted with a diagnosis of stroke to eight community hospitals in southwestern Ontario from May 2008 to December 2009 were screened for in-patient rehabilitation eligibility using the Stroke Rehabilitation Candidacy Screening Tool.
Book review: Mark Greaney continues Tom Clancy's legacy in 'Commander in Chief' - Fredericksburg.com: Books
“COMMANDER in Chief” is another home run for Mark Greaney in perpetuating Tom Clancy’s legacy of political-action thrillers. Reprising Jack Ryan and his son, as U.S. president and an offthebooks “Campus” operative, respectively, the book has everything readers have come to expect. Familiar characters from the Ryan administration and the Campus, a CIA blackops contractor, once again are striving against the odds to do their best to save their country in difficult circumstances.
Book review: Koontz raises the bar with latest thriller, "Ashley Bell" - Fredericksburg.com: Books
Book review: Koontz raises the bar with latest thriller, "Ashley Bell" More Information ASHLEY BELL By Dean Koontz (Bantam, $28, 576 pp.) Posted: Sunday, December 20, 2015 12:00 am Book review: Koontz raises the bar with latest thriller, "Ashley Bell" By MATTHEW MEYER/FOR THE FREE LANCE–STAR Fredericksburg.com | 0 comments "Ashley Bell” by Dean Koontz is an extraordinary story about imagination and transformation.
Exit: Rebellion
Campaign Rewards FAQ Community Wolf Neck Publishing presents If you were lucky enough to have grabbed the Exit Saga’s Teaser issue that was kickstarted in the summer of 2023, you have seen a glimpse of what’s in store. If you weren’t lucky enough to have grabbed that issue loaded with easter eggs, you still can if our Kickstarter unlocks that feature. How do we unlock features?
Celestial Elegance: Silver Plume Pendant Necklace
$320 pledged of $370pledged of $370 goal All or nothing. This project will only be funded if it reaches its goal by Wed, December 27 2023 4:06 AM UTC +00:00. Celestial Elegance: Silver Plume Pendant Necklace Phoenix feather: a path towards renewal. Celestial Elegance: Silver Plume Pendant Necklace Phoenix feather: a path towards renewal. $320 pledged of $370pledged of $370 goal All or nothing. This project will only be funded if it reaches its goal by Wed, December 27 2023 4:06 AM UTC +00:00.
The Dohyo's 2023 Holiday-Type Thing-a-ma-ganza!!
Campaign Rewards FAQ 3 Community Hello! Welcome to our Kickstarter for The Dohyo's 2023 Holiday-Type Thing-a-ma-ganza! The Story begins in 2020...
New Monster Movie BAKEMONO No CGI Horror Film
Campaign Rewards FAQ Community Bakemono (pronounced bah-kay-mow-noh) is the Japanese word for "monster" but a more direct translation of bake would be "changing" while mono would be "thing." This is an independent feature film shot in Tokyo by an American writer/director. I love 1980s practical FX horror movies so my dream was to make something similar in Japan where I've been living the past 5 years.
Dopecat Comics “Blazin’ da High Seez”- Funny animals smoking
Campaign Rewards FAQ Community -- Dopecat Comics is a new wave of underground comicbooks starring the sensational Dopecat, a cool cat who gets his kicks smoking blunts and chasing hoes. This issue features Drunky Duck, Dirty Rat and Dogshit Dog on a boat ride to Fukivino. We also got a special strip by the hot new Seattle based artist Atom Ivan. So sit back, spark a bowl and enjoy the trip. Dopecat Comics is an underground comic and could be found offensive to normal citizens.
Skeletens
This is our second kickstarter and we are feeling confident that we can handle any challenges that may arise. We are working with new printers, which could be a challenge, however they come highly recommended and they have worked with a lot of different kickstarters. Global shipping is still a bit of a bumpy road at times, however we plan to use a fulfilment centre close to our average backers.
Projectile Discfunction Brand Launch
At Projectile Discfunction, our vision extends beyond just innovative tournament formats and pop-up events; it's also deeply rooted in our passion for disc golf apparel. We believe that clothing should embody the carefree spirit and fun-loving essence of the sport. Our jerseys, polos, and other items are not just pieces of fabric; they're expressions of the joy and camaraderie that disc golf brings. We want players to step onto the course feeling comfortable, confident, and ready for a great time.
PANTONIA | Wideless Wood Hanger
Campaign Rewards FAQ 1 Community Every color is a vibration, much like sounds in music. Colors vary from one another in their frequencies, akin to the notes on a piano. When I create each hanger, I play with color much like a musician plays a melody with a musical instrument. I convey my emotions by combining shades of color, infusing my mood into the item, and playing my own form of 'jazz. Also, my goal was to come up with a better alternative to the regular wall hangers.
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