Matthew Peach

Abstract DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the essential licensing factor CDT1. Although geminin’s function is crucial for genomic stability, its inhibitory mechanism remains elusive. Here, we utilise a fully reconstituted human DNA replication licensing assay to dissect geminin’s role.

17 Sep 2025 Photonics and sensing technologies are key enablers to diverse application developments. by Matthew Peach in Madrid Monday afternoon saw a trio of distinctive and very different plenary talks at this week’s SPIE Sensors + Imaging conference and exhibition at the IFEMA Conference Center in Madrid, Spain.

06 Aug 2025 SPIE’s Jennifer O’Bryan details issues around Trump’s policies and how industry can respond. By Matthew Peach in San Diego SPIE Government Affairs Director Jennifer O'Bryan yesterday presented attendees to Optics & Photonics 2025 with an overview of actions by the Trump administration and U.S. Congress that have impacted the photonics community, as well as what SPIE is doing in reaction.