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Matthew Sung

As seen in: Nature
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Articles by Matthew Sung

Normalized membrane ratio of TROP2 as a predictor of clinical outcomes with datopotamab deruxtecan in non-small-cell lung cancer

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By Marina C. Garassino, Myung-Ju Ahn, Markus Schick, Ansh Kapil, Luis Paz-Ares, Aaron Lisberg, Melissa Johnson, Maurice Pérol, Toshio Shimizu, Rebecca S. Heist, Alexander Spira, Isamu Okamoto, Nicolas Girard, Robin Cornelissen, Elvire Pons-Tostivint, Min Hong, Ricardo Zwirtes, Rachel Chiaverelli, Marlon C. Rebelatto, Chuyu Deng, James Harper, Danielle Carroll, Jacob Sands, Matthew Sung, Hadassah Sade
| Nature Verified
Abstract Datopotamab deruxtecan (Dato-DXd)—a trophoblast cell surface antigen 2 (TROP2)-directed antibody–drug conjugate—has demonstrated efficacy in patients with advanced nonsquamous non-small-cell lung cancer (NSCLC) ± actionable genomic alterations. However, TROP2 expression by pathologist assessment using conventional immunohistochemistry with visual scoring does not predict response to TROP2-directed antibody–drug conjugates in NSCLC.
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