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Min Hong

Seoul
As seen in: Nature, Cell Reports, Canadian Journal of Infectious Diseases & Medical Microbiology

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Articles

YH42946, a novel and selective tyrosine kinase inhibitor, demonstrates potent antitumor activity against EGFR exon 20 insertion mutations and HER2 alterations in NSCLC

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By Dong Kwon Kim, Min Hong, Kwangho Lee, Jii Bum Lee, Byoung Chul Cho, Yun Joo Joo, Hyeon Bin Cho, Jin Hwi Park, Eunjeong Jeong, Sun Min Lim
| Nature Verified
Abstract EGFR exon 20 insertion mutations and HER2 alterations are oncogenic drivers in non–small cell lung cancer (NSCLC) with limited therapeutic options. YH42946 is an orally available tyrosine kinase inhibitor designed to selectively target these alterations while sparing EGFR wild-type. Here, we evaluated the in vitro and in vivo antitumor efficacy of YH42946.
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Constitutive DUSP2 expression enhances lymphoid cell proliferation by activating CDK1 and promotes lymphomagenesis

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By Yu Qian, Jutatip Panaampon, Bjoern Chapuy, Xueyan Zhang, Xiujuan Zhao, Zhe Wang, Pengfei Zhang, Qiang Ke, Jing Zhong, Ping Yuan, Lei Zhang, Min Hong, Il-Kyu Choi, Jiankun Guan, Dinis Pedro Calado, Scott J. Rodig, Olga Pozdnyakova, Klaus Rajewsky, Susana Godinho, Siwanon Jirawatnotai, Hao Wu, Margaret A. Shipp, Stephanie K Dougan, Baochun Zhang, Tongchai Payungwong, Aretina Zhang
| Cell Reports Verified
Keywords DUSP2, PAC-1 immune cell hematologic malignancies lymphomagenesis cell cycle CDK1 CDC25 Research topic(s) CP: Cancer CP: Immunology Introduction Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases that can dephosphorylate both tyrosine and serine/threonine residues. In humans, the DUSP family comprises 23 members.
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Minimal twin structures enabling extraordinary thermoelectric power factor of n-type Bi 2 Te 3 thin films

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By Haoran Ge, Rui Cheng, Wei Liu, Jiamin Qiu, Sen Xie, Zhaohui Wang, Fan Yan, Qiwei Tong, Tingting Su, Yujie Ouyang, Xianda Li, Zhengfei Wei, Jun Mao, Yong Liu, Huangshui Ma, Min Hong, Dongwang Yang, Ctirad Uher, Qingjie Zhang, Xinfeng Tang, Jiahong Cheng
| Nature Verified
Abstract Boosting carrier mobility is essential for achieving high room-temperature thermoelectric performance in n-type Bi2Te3-based films, which have long exhibited inferior power factors compared with their single crystal counterparts due to poor carrier mobility. To overcome this challenge, we develop a simple substrate surface engineering strategy to fabricate Twin-free n-type Bi2Te3 (000 l) thin films.
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