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Articles

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

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By Tushar D. Bhagat, Yiyu Zou, Joelle Baddour, Abhinav Achreja, Lifeng Yang, Brijesh Patel Verified, Gaurav Choudhary, Srinivas Aluri, Sanchari Bhattacharyya, Matthias Bartenstein, Masako Suzuki, Davendra Sohal, Sonal Gupta, Paola A. Guerrero, Surinder K. Batra, Michael Goggins, Ulrich Steidl, John M. Greally, Kith Pradhan, Deepak Nagrath, Anirban Maitra, Dagny Von Ahrens, Meelad Dawlaty, Hongyun Zhao, Changsoo Kwak, Shanisha Gordon-Mitchell, Srabani Sahu, Yiting Yu, Orsi Giricz, Beamon Agarwal, Debabrata Banerjee
| eLife
Abstract Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including CXCR4.
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Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

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By Tushar D. Bhagat, Albert Einstein College, Si Chen, Matthias Bartenstein
| cancerres.aacrjournals.org
Molecular and Cellular Pathobiology Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/?-Catenin Activation Tushar D. Bhagat, Si Chen, Matthias Bartenstein, A. Trevor Barlowe, Dagny Von Ahrens, Gaurav S. Choudhary, Patrick Tivnan, Elianna Amin, A. Mario Marcondes, Mathijs A. Sanders, Remco M.
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