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Matus Kolarik

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Articles

Metformin-mediated immunometabolic rewiring attenuates type I interferon-driven dendritic cell inflammation in STAT1 gain-of-function

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By Zuzana Parackova, Ondrej Vladyka, Petra Vrabcova, Violeta Bakardjieva-Mihaylova, Anna Sediva, Marketa Bloomfield, Klara Sabatkova, Matus Kolarik, Faezeh Haddadi Sisakht, Irena Zentsova, Julia Starkova
| Nature Verified
Abstract Gain-of-function (GOF) mutations in STAT1 are associated with immune dysregulation, impaired antifungal immunity and features of chronic type I interferon pathway activation. Here, we investigated whether metformin, a widely used metabolic modulator, can attenuate inflammatory dendritic cell activation in STAT1 GOF.
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