Mau-Sun Chang on Muck Rack

Mau-Sun Chang

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ARHGAP39 plays an essential role in anxiety-like behavior and stress response

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By Shin-Meng Deng, Yu-Ju Chen, Wei-Chien Hung, Kuan-Yu Wu, Irene Cheng, Guo-Jen Huang, Wei-Che Chang, Mau-Sun Chang
| Nature
Abstract Anxiety is a common mental health disorder marked by heightened stress responses and impaired emotional regulation. While the hippocampus and the hypothalamic–pituitary–adrenal (HPA) axis play key roles in regulating anxiety, the molecular mechanisms remain incompletely understood. In this study, we identified a strong link between ARHGAP39 function and anxiety using brain-specific Arhgap39 conditional knockout (cKO) mice.
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