Mauriz Anton Lichtenstein on Muck Rack

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Bottom-up reconstruction of functional Death Domain Signalosomes reveals a requirement for polymer stability and avidity

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By Fakun Cao, Mauriz Anton Lichtenstein, Finn Lobnow, Paulina Dirvanskyte
| biorxiv.org
Abstract A key feature of innate immune signaling is the compartmentalization of signaling effectors into cellular structures referred to as signalosomes. Critical to the formation of these compartments are protein polymers composed of Death Domains (DD). However, the biophysical properties these polymeric scaffolds require for signal transduction are not clearly defined.
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