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Articles

Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition

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By Johannes Gutenberg Mainz, Virginia Busetto, Vienna Biocenter Campus, Max Perutz Lab
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Significance In cells, proteins phase separate and form condensates. These protein condensates can play important role in bringing molecules together and facilitate biochemical processes. In this work, we used molecular dynamics simulations to understand how MUT-16 phase separates and forms the scaffold of the so-called Mutator focus. Mutator foci produce small RNA which help to regulates genes.
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