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Articles by Max Ticó
Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods
Abstract Selenoproteins incorporate the rare selenium-containing amino acid selenocysteine (Sec) and play crucial roles for redox homeostasis, stress response, and hormone regulation. Sec is inserted by co-translational recoding of the UGA codon, normally a stop. As a consequence, selenoproteins are often misannotated in public databases and require specialized bioinformatic methods and resources.
Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Ticó M, Sullivan E, Guigó R, Mariotti M (2026) Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases. PLoS Comput Biol 22(1): e1013885.
An updated view of the vertebrate selenoproteome reveals convergent depletions in tetrapods and expansions in ray-finned fishes
Abstract Selenoproteins incorporate the rare selenium-containing amino acid selenocysteine (Sec) and play crucial roles for redox homeostasis, stress response, and hormone regulation. Sec is inserted by co-translational recoding of the UGA codon, normally a stop, so that specialized methods are required for selenoprotein bioinformatics. Here, we present a refined characterization of the composition and evolution of the vertebrate selenoproteome.
Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases
Abstract Selenocysteine (Sec) is a non-canonical amino acid incorporated into selenoproteins, oxidoreductase enzymes carrying essential roles in redox homeostasis. Sec insertion is performed in response to the UGA codon, normally interpreted as a stop codon, but recoded in selenoprotein mRNAs. Owing to the dual function of UGA, the identification of selenoprotein genes poses a challenge. We show here that the vertebrate selenoprotein genes are widely misannotated in the major public databases.
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