Maxat Kulmanov

Abstract Kinase activity is increasingly linked to biomolecular phase separation. Focal adhesion kinase (FAK) forms membrane-associated condensates with paxillin to promote adhesion. Here we show that its paralogue, proline-rich tyrosine kinase 2 (PYK2), undergoes phase separation via a distinct mechanism. PYK2 forms cytoplasmic condensates primarily driven by its kinase–FAT linker (KFL) region.

Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001540 Metrics Download as PowerPoint /deliver/fulltext/mgen/11/11/mgen001540.html?itemId=/content/journal/mgen/10.1099/mgen.0.001540&mimeType=html&fmt=ahah References Jevons MP. “Celbenin” - resistant Staphylococci. BMJ 1961; 1:124–125 [View Article] [Google Scholar] Katayama Y, Ito T, Hiramatsu K. A new class of genetic element, Staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus.

Abstract The selection of a reference sequence in genome analysis is critical, as it serves as the foundation for all downstream analyses. Recently, the pangenome graph has been proposed as a data model that incorporates haplotypes from multiple individuals. Here we present JaSaPaGe, a pangenome graph reference for Saudi Arabian and Japanese populations, both of which have been significantly underrepresented in previous genomic studies.