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Maximilian Bardo

As seen in: SAGE Publishing
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Articles

Methods for non-proportional hazards in clinical trials: A systematic review

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By Norbert Benda, Jonas Brugger, Maximilian Bardo, Cynthia Huber
| SAGE Publishing
1. Introduction In clinical studies with time-to-event outcomes, it is commonly assumed that the hazard functions of the treatment groups are proportional. However, several scenarios can lead to non-proportional hazards (NPHs). Figure 1(a) and (b) illustrate the hazard ratio (HR) of a delayed and a diminishing treatment effect, respectively.
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