Maximilian Lenz on Muck Rack

Maximilian Lenz

As seen in: Rheinische Post, Color Research & Application, Wiley Online Library, Springer, Frontiers, MDPI, Royal Society of Chemistry, eLife
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Articles

Frontiers | Synaptic transmission in supragranular layers of the human cortex – comparative review of structure, function, and plasticity

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By Amelie Eichler, Pia Kruse, Maximilian Lenz, Charlotte Schob
| Frontiers
Introduction Higher brain function relies on orchestrated interactions between neurons in complex networks. Synapses are specialized contact sites between neurons that collocate signal transmission and storage, which underlines their essential role in physiological network function. Therefore, synaptic transmission and plasticity, both on structural and functional levels, were intensely investigated over the last decades in various cell culture models and living animals.
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Standardized protocol for plasticity assessment in the aging mouse neocortex using choline-chloride perfusion

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By Pia Kruse, Charlotte Schob, Kerstin Schwabe, Maximilian Lenz
| Frontiers
Abstract Age-related changes in synaptic function are central to the progression of brain pathologies, including neurodegenerative diseases, underscoring the need for experimental approaches that capture neuronal properties across the lifespan. However, obtaining high-quality tissue preparations from aged animals that permit combined structural and functional analyses of individual neurons is challenging due to increased tissue vulnerability.
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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks

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By Han Lu, Sandra Diaz-Pier, Maximilian Lenz, Andreas Vlachos
| eLife
eLife Assessment This valuable study combines experiments and modelling to advance our understanding of the nonlinear nature of homeostatic structural plasticity and its interaction with synaptic scaling. The methodology and findings are solid, although additional work is needed to better link models with experiments and support some of the conclusions drawn. This study will be of interest to theoretical and experimental neuroscientists working in homeostatic plasticity.
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