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Maximillian A Robinson on Muck Rack

Maximillian A Robinson

As seen in: BioRxiv
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Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

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By Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Maximillian A Robinson
| BioRxiv
Abstract The CTLA-4 and PD-1 checkpoints control immune responses to self-antigens and are key targets in cancer immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1 respectively. This cis interaction prevents PD-1 binding to PD-L1 but is reversed by CTLA-4 trans-endocytosis of CD80. However, the mechanism by which CTLA-4 selectively removes CD80 but not PD-L1 is unclear.
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