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Maximo-Ibo Galindo on Muck Rack

Maximo-Ibo Galindo

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Articles

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models - Nature Communications

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By David Fabregat-Safont, Tobias Eisenberg, Jesus Gomez, Adrián Plaza, Manuel Perez, Manuel Pérez, Sebastian J. Hofer, Christoph Magnes, Oscar J Pozo, Mari Carmen Gómez-Cabrera, Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Álvaro Ballesteros-Gonzalez, Janet S. Duerr, Maximo-Ibo Galindo
| Nature Verified
Abstract Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, improves mitochondrial function and metabolic parameters, and extends healthspan.
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