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Submitted: 14 October 2025 You are already at the latest version Progesterone (P4) withdrawal is the key trigger for labor onset. Labor is a sterile inflammatory process involving monocyte infiltration, differentiation into M1 or M2 macrophages (Macs) and contributing to the inflammatory milieu in the uterus. Premature leukocyte influx may lead to preterm birth.
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