May Yoon Pwint

Abstract Microelectrode arrays (MEAs) are devices capable of recording extracellular action potentials (spikes) from many neurons simultaneously and with high spatial and temporal resolution. MEAs have emerged as an invaluable tool for understanding how networks of neurons govern complex sensory, motor and decision-making processes. In this Primer, we introduce various in vivo MEA designs and describe their construction, characterization and applications.

Introduction Click to copy section linkSection link copied! Glutamate (GLU) is an important neurotransmitter in the central nervous system. As the primary excitatory neurotransmitter in the brain, GLU is responsible for propagating diverse signals, including those related to pain (1) and vision. (2) Abnormal GLU signaling is associated with disease states including attention deficit hyperactive disorder, (3) seizure, (4−6) and excitotoxicity.

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