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Mayarling F. Troncoso on Muck Rack

Mayarling F. Troncoso

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Articles

Endothelial extracellular vesicles preserve vascular smooth muscle cell identity but do not reverse endothelial senescence

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By Úrsula Zúñiga-Cuevas, Leslye Venegas-Zamora, Magda C Díaz-Vesga, Ximena Calle-Chalco, Andrés Ramírez-Reyes, Alejandra Hernandez, Sebastián Urquiza-Zurich, Mayarling F. Troncoso, Ignacio Norambuena-Soto, Mario Chiong, Valentina Parra, Sergio Lavandero, Jaime A. Riquelme, Vania Otárola-Urrutia, Camila López-Torres, Javiera Favi-Coloma, Constanza Rimassa-Taré, Danica Jiménez-Gallegos
| Nature Verified
Abstract Vascular aging is characterized by endothelial senescence and vascular smooth muscle cell (VSMC) phenotypic switching, yet the role of endothelial extracellular vesicles (EVs) in these processes remains unclear. We show that EVs from non-senescent endothelial cells prevent PDGF-BB–induced VSMC dedifferentiation, preserving contractile markers and limiting migration.
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17-beta estradiol prevents cardiac myocyte hypertrophy by regulating mitochondrial E3 ubiquitin ligase 1 - Cell Death & Disease

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By Emanuel Guajardo-Correa, angelica ortega, Ángel Raya, Vinicius Maracaja-Coutinho, Mario Chiong, Valentina Parra, Ximena Calle, Valeria Garrido-Moreno, Brenda Becerra, Mayarling F. Troncoso, Juan Francisco Silva-Agüero, Leslye Venegas-Zamora, Erik Lopez-Gallardo, Felipe Muñoz-Córdova, Fernanda Fredericksen, Sebastian Aedo-Cares, Allan Peñaloza-Otárola
| Nature Verified
Abstract Cardiac hypertrophy is a cellular process characterized by the increased size of cardiomyocytes in response to a high workload or stress. 17-beta estradiol (E2) has cardioprotective and anti-hypertrophic effects by maintaining mitochondrial network and function. MUL1 is a mitochondrial ubiquitin ligase directly involved in the control of mitochondrial fission and mitophagy.
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