Mbong Eta Ngole

Introduction Malaria is a vector-borne disease caused by parasites of Plasmodium species that are transmitted to people through the bites of infected female Anopheles mosquitoes and is one of the major public health problems worldwide. In 2021, there were 247 million estimated cases of malaria worldwide, and 619,000 estimated malaria-related deaths. The World Health Organization (WHO) African Region carries a disproportionately high share of the global malaria burden (1).

In this study, we found that both preexposure and postexposure vaccination with rVSV-ZEBOV was associated with a reduction in EVD symptoms and deaths in laboratory-confirmed, EVD-positive patients. Vaccinated patients had a lower viral load upon admission and had fewer EVD-associated symptoms overall than their unvaccinated counterparts. Vaccinated persons were slightly older and more likely to have reported contact with a suspected or confirmed EVD-positive person.