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Articles

Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries

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By Daniel Rabe, Matthew Weller, Bhoktear Khan, Cristiane M. Franca, Alice Corrêa Silva-Sousa, Amin Mansoorifar, Avathamsa Athirasala, Ramesh Subbiah, Anthony Tahayeri, Mauricio Sousa, Keith Beadle, McKenna Finley, May Anny Fraga, Rahul M. Visalakshan, Aaron Doe, Emilios Dimitri
| Science Magazine Verified
Abstract A hallmark of chronic and inflammatory diseases is the formation of a fibrotic and stiff extracellular matrix (ECM), typically associated with abnormal, leaky microvascular capillaries. Mechanisms explaining how the microvasculature responds to ECM alterations remain unknown.
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